The Hygiene Hypo Overview

My blog exercise was about the Hygiene Hypothesis, which is the absence of exposure to infectious parasites and microbes in early stages of childhood, preventing the immune system natural growth and development.  More diseases are developing in young children today because we are not enabling them to be exposed to the natural microbes our immune system needs to keep us healthy.  Therefore because of this autoimmune diseases for example like rhinitis, asthma, and eczema are on the rise in cleaner more industrialized countries.  I learned that there may be a possibility that humans can actually be to clean, and the Hygiene Hypothesis provides us with the knowledge that germs can actually be good for us and is essential for the prevention of present and possible future illnesses. 

            Research data reveals to us that in only just a few passing decades’ signs of the manifestation of the allergic reactions have significantly increased; but why?  I found out that 37 million bacteria are added to the air in a room by just one single person every hour!  Population has accumulated and is becoming a problem, but if 37 million bacteria are added by every human every hour why?  It is because lifestyles have changed in different food habits as well as our living conditions.  Humans have formed better hygiene methods and are “cleaner,” but these “cleaner” atmospheres are expelling the microbes our bodies need to fight against threatening viruses and autoimmune diseases.  As soon as a child loses out on these natural microbes there is no replacing with another set after they haven’t been provided.  Scientist did research on labratory mice to understand these things for example what the T cells do in relation of having a cleaner environment.  These experiments have helps us understand how the human body would work.

Studies show prevention from larger families verses smaller families, farm environment verses rural environment, and largely populated cities verses country towns.  Although there is nothing we can do about the world growing and becoming more industrialize, so what will be done to prevent harmful autoimmune disease and our children?  Should doctors limit the use of antibiotics in the early stages of development?  And, where do we go from here with our hypothesis?  These questions and more are wondered and discussed as you read further into the relationship with microbials and the immune system with the Hygiene Hypothesis.

In Conclusion!

Now we see that our immune system has a relationship with microbial exposure, and to decrease any form of microbial exposure will be hostile to us.  Allergy prevention is still a rising issue, and we are left open ended concerning what to do with our hypothesis.  Scientist have still yet to give an explanation about why all the concerning diseases are accumulating over the past few decades.  We are simply left with assuming statements, and concerns with our personal hygiene.  In conclusion, more studies need to be done which reveal more evidence of the “relationship” between microbial exposures and allergy, asthma, and auto immune diseases concerning our immune system.  New sciences that could reveal more evidence are: molecular evolutionary biology and population genetics.  More studies in these two key subjects will shed more light on the hygiene hypothesis.

 

Cause-and-Effect Schematic for the Hygiene Hypothesis

 

-          This diagram shows the relationship between microbial exposures, immune responses, and disease outcomes. The diagram indicates the genetic variables cause different immune responses and disease outcomes. Still left open ended are the genetic variables which modify responses and the outcomes.

 

 

 

 

References:

1.        Manuela, Clerici, Sironi, Mario. "The Hygiene Hypothesis: An Evolutionary Perspective." N.p., June 2010. Web. 25 Nov. 2012. <http://ehis.ebscohost.com/ehost/detail?sid=1adb4e1b-2ade-4a66-927b-934e3f014703%40sessionmgr111&vid=6&bk=1&hid=101&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=a9h&AN=51256404>.

2.       Murphy, Liu, James, Andrew. "Hygiene Hypothesis: Fact or Fiction?" ScienceDirect. Journal of Allergy and Clinical Immunology, n.d. Web. 25 Nov. 2012. <http://www.sciencedirect.com/science/article/pii/S0091674902914910>.

3.       Ring, Kramer, Behdrendt. "A Critical Approach to the Hygiene Hypothesis." A Critical Approach to the Hygiene Hypothesis. N.p., Dec. 2004. Web. 25 Nov. 2012. <http://ehis.ebscohost.com/ehost/detail?vid=3&hid=101&sid=5a9cab5c-e119-4ddd-a86b-db58b903571d%40sessionmgr110&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=a9h&AN=15373631>.

Hygiene Hypo

Should doctors limit the use of antibiotics in the early stages of human development?

This question should be considered as we become more familiar with rise of autoimmune diseases via The Hygiene Hypothesis. As we look into early exposure to germs during the most vital growth period of human beings we relate our research on laboratory experiments on mice. As we have observed with people in the more or less populated and cleanly environments, scientist put the hypothesis to the test with mice. Does early exposure to bacteria effect autoimmune disease in the adult stage? With two sample groups of mice, one raised in a germ free environment and other in a normal environment, the result showed proof. Allergies, asama, and other autoimmune diseases were developed in the germ free mice. Researched looked closer and saw killer T cells that normally fight off infection were becoming over active and actually targeted healthy tissue. This resulted in inflammation of lungs and in the colon in the germ free, "healthier" mice. Therefore the normal mice were examined showing healthier, normal signs of growth and life. 

Kawasaki disease is a prime example of allergic malfunction that was formed in humans through the failed exposure of microbes.  On a closer level Kawasaki is caused by inflammation and the "split" in the T cells resulting in immune defect.  While there is a substantially low rate of Kawasaki in indigenous Australians, the industrialized populations show a rise.  The results of the Kawasaki disease are of the same comparison with the mice laboratory experiments, also showing proof of a more vital immune system in the native, more natural children opposed to the high rise exposure in the industrialized children.

Work Cited:

VOALearningEnglish. "Why Getting Dirty Can Be Healthy for Children." YouTube. YouTube, 01 May 2012. Web. 07 Nov. 2012. http://www.youtube.com/watch?v=o6yt9wR64B4.

"Login-Library Resources." Login-Library Resources. N.p., Nov. 2011. Web. 07 Nov. 2012. <http://libproxy.uta.edu/ehost/pdfviewer/pdfviewer?sid=806f7f03-f8ea-401b-ba14-b3ceb7fce7cf@sessionmgr15>.